Fig. 9: Diagram of the regulatory loop formed by the PA/PHF2/SREBP1c axis. | Nature Communications

Fig. 9: Diagram of the regulatory loop formed by the PA/PHF2/SREBP1c axis.

From: Palmitoylation-driven PHF2 ubiquitination remodels lipid metabolism through the SREBP1c axis in hepatocellular carcinoma

Fig. 9

Low PA cellular levels cause PHF2-mediated SREBP1c degradation (left panel). PA-enriched conditions enhance ZDHHC23-dependent PHF2 palmitoylation, resulting in the proteasomal degradation of PHF2. Following PHF2 degradation, SREBP1c becomes stable and induces PA levels in HCC cells (right panel). Finally, the vicious cycle of PA/PHF2/SREBP1c results in a poor HCC prognosis.

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