Fig. 2: NK cell response to MCMV infection in newborn mice. | Nature Communications

Fig. 2: NK cell response to MCMV infection in newborn mice.

From: Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells

Fig. 2

Newborn C57BL/6 mice were intraperitoneally infected with 200 PFU of MCMV or mock-infected 24–36 h after birth. a The indicated groups of mice were depleted of NK cells (αNK1.1). At designated time points, virus titers were determined in the spleen (n = 8 (d.p.i. 7), n = 5 (d.p.i. 12 and d.p.i. 21.)). Dashed line represents detection limit. At indicated time points, the numbers of NK cells (b), the frequency of Ly49H+ NK cells (c), the frequency of IFN-γ producing NK cells (d) (n = 5 d.p.i. 5, d.p.i. 12, d.p.i. 21 and d.p.i. 40 MCMV; n = 3 d.p.i. 40 Mock, Mann–Whitney two-tailed test), and the expression of CD69 by NK cells (e) were analyzed in the spleen. Mean values ± SD are shown. Statistically significant differences are indicated (P values). Source data are provided as a Source Data file.

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