Fig. 8: Broad transcriptional dysregulation of NK cells following perinatal MCMV infection.

a Principal component analysis (PCA) was performed for all samples using the normalized, rlog-transformed count data, and the variability over the first (PC1) and second (PC2) principal components is shown on the x and y-axis, respectively. Ellipses around each experimental group denote a 95% confidence level. b Bar plots showing a selection of significantly enriched gene ontology (GO) terms in a list of genes that are deregulated in KLRG1⁺ NK cells following MCMV infection of newborn mice. c Heat map illustrating the differences in expression of transcription factors in KLRG1⁺ and KLRG1^- NK cells from MCMV-infected mice and KLRG1^- from mock-infected mice. d, e Expression of TCF-1 and BLIMP-1 was analyzed in KLRG1^- NK1.1⁺ cells from mock-infected mice and KLRG1^- and KLRG1⁺ NK1.1⁺ cells from MCMV infected mice 21 days p.i. by flow cytometry. Representative histograms and quantification of TCF-1 and BLIMP-1 expression by NK cells are shown. Mean values ± SD are shown (n = 5 mice per group, One-way ANOVA test was used). P values are shown. Source data are provided as a Source Data file.