Table 1 Lipid composition and surface modifications of LNP variants
Composition (Mol%) | LNP | LNPa | LNPx | LNPz |
|---|---|---|---|---|
MC3 | 50 | 50 | 50 | 50 |
DSPC | 10 | 10 | 10 | 10 |
Cholesterol | 38.5 | 38.5 | 38.5 | 38.5 |
DMG-PEG2k | 1.5 | 1.2 | 1.2 | 1.2 |
DSPE-PEG-2k- Amine | 0 | 0.3 | 0 | 0 |
DSPE-PEG-2k- Carboxy NHS | 0 | 0 | 0.3 | 0 |
DSPE-PEG-2k- Carboxylic Acid | 0 | 0 | 0 | 0.3 |
