Table 2 Summary of all crystal structures of MLKL pseudokinase domain to date

4MWI

Human

–

–

190–471

C 2 2 2₁

Yes

Yes

In

⁴²

8SLZ

Human

pT357/pTS358

–

190–471

C 2 2 2₁

Yes

Yes

In

This study

4M67

Human

–

–

179–471

C 2 2 2₁

Yes

Yes

In

⁵⁴

6LK6

Human

T357A/S358A

–

179–471

C 2 2 2₁

Yes

Yes

In

⁵²

6LK5

Human

T357E/S358D

–

179–471

C 2 2 2₁

Yes

Yes

In

⁵²

6BWK

Human

T357E/S358E

–

190–471

C 2 2 2₁

Yes

Yes

In

⁴⁰

5KO1

Human

–

Compound 4

(Type I inhibitor)

191–471

C 2 2 2₁

Yes

Yes

In

⁵⁵

5KNJ

Human

–

Compound 1

(Type II inhibitor)

191–471

P 2₁ 2₁ 2₁

Yes

No

Out

⁵⁵

6O5Z

Human

–

Compound 2

(Type II inhibitor)

190–471

P 2₁

Yes

No

Out

⁵⁶

7JW7

Human

–

Mb27 (protein)

190–471

P 3₁ 2 1

Yes

Yes

In

³³

7JXU

Human

–

Mb32 (protein)

190–471

P 4₃

No

No

In

³³

7MON

Human

–

RIPK3 (protein)

190–471

P 2₁ 2₁ 2₁

No

No

In

²⁹

4BTF

Mouse

–

–

1–464

P 2₁ 2₁ 2₁

No

No

In

³²

4M69

Mouse

–

RIPK3 (protein)

182–464

C 2 2 2₁

No

No

Out

⁵⁴

4M68

Mouse

–

–

182–464

P 2₁

No

No

In

⁵⁴

6VC0

Horse

–

–

188–475

C 2

Yes

Yes

In

³⁶

6VBZ

Rat

–

–

179–464

P 6₁ 2 2

Yes

Yes

In

³⁶