Fig. 6: Association of TSH PGS with age-of-onset of hypothyroidism and hyperthyroidism.

Proportion of hypothyroidism (a, left) and hyperthyroidism (b, right) cases diagnosed by age stratified into lowest (grey), median (blue) and highest (yellow) decile for the TSH PGS. Shaded bands indicate 95% confidence intervals. Sample size: Hypothyroidism, 29,550 cases and 368,691 controls; Hyperthyroidism, 5549 cases and 392,692 controls. Statistical tests were two-sided.