Fig. 2: The nucleus reuniens displays theta-range rhythms that correlate with conditioned freezing across extinction learning.
From: Thalamic nucleus reuniens coordinates prefrontal-hippocampal synchrony to suppress extinguished fear
A Illustration and (B) raw traces of bipolar electrophysiological field recordings from the RE. C Behavioral timeline showing that field recordings took place during fear extinction after all rats were conditioned the previous day in distinct contexts. D Average freezing behavior (n = 4; 2 male and 2 female) during fear extinction training. Baseline subtracted spectrograms showing increased 3–6 Hz power (E) during the first five trials of extinction (Early) and increased 6–9 Hz power (F) during the last five trials of extinction (Late). G Average normalized power for 3–6 Hz oscillations decreased from early to late extinction, whereas 6–9 Hz power increased (p = 0.041, two-way ANOVA). Relationship of freezing behavior vs 3–6 Hz power (H) and 6–9 Hz power (I). RE = nucleus reuniens of the thalamus, CS conditioned stimulus. Line plots represent mean ± s.e.m.s. *p < 0.05. Source data are provided as a Source Data file.
