Fig. 4: Pharmacological inactivation of RE impairs mPFC-HPC synchrony.
From: Thalamic nucleus reuniens coordinates prefrontal-hippocampal synchrony to suppress extinguished fear
A Illustration depicting electrode and cannula placements. B Representative photomicrograph showing injector tip placement in the RE. Similar photomicrographs were taken to confirm placements for all animals. C Behavioral timeline. D Average freezing behavior (n = 11; 8 male and 3 female) across fear conditioning and extinction. E Freezing behavior showing that muscimol inactivation of the RE impairs extinction retrieval. F Average theta-range spectral coherence between the mPFC and HPC after either muscimol or saline infusion in the RE. Muscimol inactivation of the RE impaired IL-HPC 6–9 Hz coherence (p = 0.017, two-way ANOVA with Bonferroni correction). mPFC medial prefrontal cortex, HPC hippocampus, RE nucleus reuniens of the thalamus. Line plots represent mean ± s.e.m.s; boxplots represent mean plus minima and maxima with lower and upper quantiles. *p < 0.05. Source data are provided as a Source Data file.
