Fig. 9: SMN shuttling during DNA damage/repair dependent nucleolar reorganization. | Nature Communications

Fig. 9: SMN shuttling during DNA damage/repair dependent nucleolar reorganization.

From: Nucleolar reorganization after cellular stress is orchestrated by SMN shuttling between nuclear compartments

Fig. 9

After genotoxic stress, RNA Polymerase 1 (RNAP1 in green), Fibrillarin (FBL in red) and nucleolar DNA (rDNA in blue) are exported to the periphery of the nucleolus. During DNA repair, Coilin (in purple) and subsequently SMN (in yellow) shuttle from Cajal bodies to the nucleolus. Once DNA repair is fully completed, the organization of the nucleolus is restored. The shuttling of SMN relies on the presence of Coilin and the activity of PRMT1. The restoration of the nucleolar structure is dependent on FBL and SMN.

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