Fig. 4: Performance of RPET metabolic fingerprints for T2DM stratification. | Nature Communications

Fig. 4: Performance of RPET metabolic fingerprints for T2DM stratification.

From: Metabolic fingerprinting on retinal pigment epithelium thickness for individualized risk stratification of type 2 diabetes mellitus

Fig. 4

a Progressive increase of T2DM events across RPET metabolic states. b Cumulative T2DM hazard over the follow-up period, stratified by RPET metabolic state quartiles. Data are presented as observed event frequency and 95% confidence intervals. Red indicates top quartiles; sky blue indicates second quartile; green indicates third quartile; navy indicates fourth quartile. c Receiver operating characteristic curves of clinical indicators alone versus the combination of clinical indicators and RPET metabolic states. d Net benefit curves of clinical indicators alone versus the combination of clinical indicators and RPET metabolic states. Orange indicates clinical indicators only; blue indicates the combination of clinical indicators and RPET metabolic states; horizontal dotted gray line indicates treat none; and vertical dot-dash gray lines indicates treat all. Source data are provided as a Source Data file. RPET retinal pigment epithelium thickness, T2DM type 2 diabetes mellitus; AUC area under receiver operating characteristic curve.

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