Fig. 7: Comparison of the binding activity of different human antibodies to Delta and Omicron variants.
From: Defining neutralization and allostery by antibodies against COVID-19 variants
a Antibody binding activity to Delta and Omicron variants of Spike compared with Wuhan-Hu-1 strain (HexaPro, purified from mammalian cell culture). Antibodies at concentrations from 10 pg/mL–10 µg/mL were tested for binding to SARS-CoV-2 Spike and MBP-RBD by ELISA, shown with their EC50 values indicated. Data was collected (n = 3 independent experiments) and represented as mean ± error bars (SEM). Heat map of differences in deuterium exchange for b–d LSI-CoVA-014 and e–g LSI-CoVA-016 antibody complexes with isolated RBD variants (b, e) RBDδ (PDB: 7W98), c, f RBDo1 (PDB: 7WPA), and d, g RBDo2 (PDB: 7WPA) as compared to apo states. Cryptic epitope sites are highlighted in yellow. Source data is provided as Source data file.
