Table 2 Characteristics and biochemistry of patients at the time of blood sampling
From: Intestinal Atp8b1 dysfunction causes hepatic choline deficiency and steatohepatitis
Control subjects (n = 31) | PFIC1 pre-LTx (n = 10) | PFIC1 post-LTx (n = 12) | Other cholestasis pre-LTx (n = 27) | Other cholestasis post-LTx (n = 20) | |
|---|---|---|---|---|---|
Year of birth | 2016 (2014 to 2017) | 2012 (2006 to 2014) | 2004 (2000 to 2008) | 2012 (2010 to 2013) | 2010 (2005 to 2013) |
Male (%) | 56.7 | 50.0 | 41.7 | 48.1 | 55.0 |
Age (years) | 3.5 (2.1 to 5.5) | 5.5 (1.3 to 6.4) | 12.0 (9.4 to 15.0) | 3.0 (1.5 to 8.7) | 8.9 (6.3 to 11.6) |
Years after LTx | NA | NA | 7.1 (1.3 to 12.2) | NA | 7.2 (5.3 to 9.1) |
Height Z-score | −0.1 (−0.5 to 0.6) | −3.3 (−4.4 to −2.8) | −3.4 (−4.6 to −3.0) | −0.7 (−1.8 to 0.2) | −0.7 (−1.4 to 0.2) |
Weight Z-score | 0.0 (−0.5 to 0.4) | −2.0 (−2.7 to −1.2) | −1.9 (−2.2 to −1.4) | −1.1 (−1.7 to 0.3) | −0.4 (−0.7 to 0.0) |
AST (IU/L) | 31.0 (26.3 to 37.8) | 78.5 (65.5 to 134.5) | 52.5 (41.8 to 70.5) | 125.5 (66.0 to 329.8) | 34.0 (30.5 to 40.0) |
ALT (IU/L) | 13.5 (11.0 to 18.5) | 51.5 (43.0 to 91.8) | 45.0 (30.5 to 80.0) | 145.0 (40.5 to 249.0) | 22.0 (14.0 to 25.0) |
T-Bil (mg/dL) | 0.4 (0.3 to 0.5) | 5.0 (4.2 to 6.3) | 0.7 (0.5 to 0.8) | 3.1 (2.1 to 6.2) | 0.6 (0.6 to 1.0) |
D-Bil (mg/dL) | 0.1 (0.1 to 0.1) | 4.0 (3.6 to 4.9) | 0.2 (0.1 to 0.2) | 2.3 (1.0 to 4.8) | 0.2 (0.1 to 0.3) |
GGT (IU/L) | 10.0 (8.0 to 12.8) | 27.5 (25.0 to 37.8) | 24.0 (17.0 to 80.8) | 25.0 (15.3 to 42.0) | 9.0 (6.0 to 54.5) |
TBA (μmol/L) | 11.9 (6.1 to 19.5) | 222.5 (198.9 to 245.1) | 23.2 (14.4 to 49.3) | 164.8 (79.6 to 257.8) | 42.6 (32.1 to 67.6) |
