Fig. 2: Obesity does not alter bronchial epithelial cell antiviral or proinflammatory responses to influenza infection.
From: Obesity dysregulates the pulmonary antiviral immune response
a Bronchial epithelial cells from 10 obese and 13 non-obese control subjects were cultured and infected ex vivo with H1N1/09 (H1N1), seasonal H3N2 and B/Florida (B/Flo) influenza viruses. Cell supernatants were collected at 24 h. b Interferon (IFN)-α, (c) IFN-β, (d) IFN-λ, (e) IL-6, (f) CXCL-8/IL-8 and (g) TNF protein concentrations were quantified by multiplex ELISA. Graphs show datapoints for individual subjects with lines indicating median (IQR). Data analysed by Kruskal Wallis with Dunn’s post-test or Mann–Whitney U test. Significance indicated above each group compares virus infected cells to medium-treated control cells. Brackets show comparisons between non-obese and obese subject groups. ns non-significant. Source data are provided as a Source Data file.
