Fig. 5: FeN4O2-SACs effectively inhibit hyperproliferation and inflammation by scavenging ROS in vitro. | Nature Communications

Fig. 5: FeN4O2-SACs effectively inhibit hyperproliferation and inflammation by scavenging ROS in vitro.

From: Single-atom catalysts-based catalytic ROS clearance for efficient psoriasis treatment and relapse prevention via restoring ESR1

Fig. 5

a Schematic illustration of the cell experimental design and results. b, c Flow cytometry analysis of HaCaT cells in different groups stained by DCFH-DA (2,7-Dichlorodihydrofluorescein diacetate, EX498/EM530 nm) (b) and the quantification of fluorescence intensity (c). n = 3 independent experiments and data are presented as mean ± SD. d CCK-8 assay showing the cell proliferative viabilities of different groups. n = 3 independent experiments and data are presented as mean ± SD. e RT-qPCR results for the inflammatory factors TNF-α, IL-6, and IL-8 at 24 hours. n = 4 independent experiments and data are presented as mean ± SD. ***p < 0.001, **p < 0.01 versus the Control group; ###p < 0.001, #p < 0.05 versus the M5 group. Statistical significance was calculated via one-way ANOVA (c), two-way ANOVA (d), and two independent samples unpaired Student’s t test (e). Source data are provided as a Source Data file.

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