Fig. 6: FeN₄O₂-SACs effectively alleviate the psoriasis dermatitis in vivo.

a Schemes of the IMQ-induced psoriasiform model, treatments and efficacy. b Representative images of lesions on day 8, n = 4 samples/group. c, d Quantification of ear thickness (c) and PASI score (d), n = 4 samples/group and data are presented as mean ± SD. e, f Histological staining (e) and the corresponding quantifications (f). Scale bar=100 μm, n = 4 samples/group and data are presented as mean ± SD. g, h Levels of inflammatory signals, T cells, macrophages, proliferative keratinocytes and tissue-resident memory T cells analyzed by immunohistochemistry labelling of p-STAT1, p-STAT3, NF-κB p50, CD3, F4/80, PCNA and CD103 in the ear lesions on day 8 (g), and the corresponding quantifications (h). Scale bar=100 μm, n = 4 samples/group and data are presented as mean ± SD. i The mRNA expression levels of Il-17a, Tnf-α, Il-12, and Il-23 at the ear skin tissues detected by RT-qPCR. n = 4 samples/group and data are presented as mean ± SD. j, k The ROS level of ear skins from different groups detected by fluorescence probe DHE (Dihydroethidium, Filter block of spORANGE at EX532-554/EM576-596 nm) (j) and the quantification (k) of relative mean fluorescence intensity (MFI), orange color indicates the ROS-positive, n = 4 samples/group and data are presented as mean ± SD. ^***p < 0.001, ^**p < 0.01, ^*p < 0.05 versus the IMQ group; ^###p < 0.001, ^##p < 0.01, ^#p < 0.05 versus the IMQ+Cal group; ^■■■p < 0.001 versus the Control group; ns means no significance. Statistical significance was calculated via two-way ANOVA (c, d), two independent samples unpaired Student’s t test (f, h, i, k). Source data are provided as a Source Data file.