Fig. 8: FeN4O2-SACs suppress the recurrence of psoriasis-like skin dermatitis.
a IHC stainings of CD3 and ESR1 in skin tissues of normal, psoriatic, and recurrent individuals. Scale bar = 100 μm. b Relative quantifications of CD3 and ESR1 determined by ImageJ. n = 4 samples/group and data are presented as mean ± SD. ***p < 0.001 versus the Normal group. c Experimental design of IMQ-stimulated psoriasis relapse model. d Representative images of relapse models, n = 4 samples/group. e, f Quantifications of ear thickness (e) and PASI score (f), n = 4 samples/group and data are presented as mean ± SD. g Relative quantifications of histological staining. n = 4 samples/group and data are presented as mean ± SD. h, Quantifications of p-STAT1+, p-STAT3+, NF-κB p50+ signals, CD3+ T cells, F4/80+ macrophages, and PCNA+ keratinocytes in ear skin lesion tissues from different groups. n = 4 samples/group and data are presented as mean ± SD. i The mRNA expression levels of Il-17a, Tnf-α, Il-12 and Il-23 of ear skin tissues detected by RT-qPCR. n = 4 samples/group and data are presented as mean ± SD. ***p < 0.001, **p < 0.01, *p < 0.05 versus the Relapse group; ###p < 0.001, ##p < 0.01, #p < 0.05 versus the Relapse+Cal group; ■■■p < 0.001 versus the Non-relapse group; ns means no significance. Statistical significance was calculated via two-way ANOVA (e, f), two independent samples unpaired Student’s t test (b, g–i). Source data are provided as a Source Data file.
