Fig. 1: Schematic illustration of the preparation of polyethylene glycol (PEG)-coated SnS nanoparticles (SnSNPs@PEG) and their denaturation-and-penetration strategy for enhanced SDT.
From: Nanosensitizer-mediated augmentation of sonodynamic therapy efficacy and antitumor immunity
SnSNPs@PEG were prepared via the liquid-phase exfoliation method and subsequent PEGylation. The mild photothermal effect of SnSNPs@PEG increases tumor oxygen supply and denatures tumor collagen, promoting the penetration of SnSNPs@PEG to enhance SDT and kill tumor cells. This approach also boosts antitumor immunity by activating cytotoxic T lymphocytes that can infiltrate into the tumor overcoming the stromal barrier and further disrupting tumors for antitumor effects. The figure was created with Biorender.com.
