Fig. 5: Phase precession and ripple participation of aAP- and nAP-Pyr cells.
From: Aversive stimulus-tuned responses in the CA1 of the dorsal hippocampus
a Theta phase precession of two representative aAP-Pyr cells (left panels) and two representative place cells (right panels). Dots mark individual spikes. b Paired plots showing individual phase ranges of theta phase precession for aAP-Pyr cells exhibiting phase presession (left panel) and place cells (right panel). Left and right sides of the diagrams are corresponding to start and stop phase distributions, respectively. Two consecutive theta cycles are presented for illustrative purposes. Left side represents start phase and right side represents stop phase. Start phase: aAP-Pyr cells’ vs. place cells’ 29.6 ± 34.1° vs. 146.9 ± 32.2°, Watson-Williams-test p < 10−3. Stop phase: a-AP-Pyr cells’ vs. place cells’ 283.8 ± 28.3° vs. 326.1 ± 30.9°, Watson-Williams-test p = 7.8 ×10−4. c Phase range of aAP-Pyr cells exhibiting phase precession (n = 46, aAP) and nAP-PC cells (n = 130, PC). Phase range, aAP cells: 126.2 ± 9.0° vs. place cells: 183.4 ± 7.2° Wilcoxon-Mann-Whitney-test **p = 1.38×10−5. d Cumulative distribution of ripple participation of aAP-Pyr cells (violet line) and air puff-nonresponsive pyramidal cells (grey line). Kolmogorov-Smirnov test: p = 0.004. e Summarized ripple participation of aAP-PC cells (n = 82), aAP-nPC cells (n = 46), nAP-PC (n = 349) and nAP-nPC cells (n = 306), Kruskal-Wallis test H(3) = 145.7, p < 0.005, There is significant difference between each group except of aAP-nPC vs. nAP-PC with Dunn-Holland-Wolfe post hoc test. f Spike number ratio (total number of spikes during ripple / spike numbers during quiet wakefulness) of an aAP-PC cells (n = 82), aAP-nPC cells (n = 46), nAP-PC (n = 349) and nAP-nPC cells (n = 300), Kruskal-Wallis test H(3) = 17.6, p < 0.005. Post hoc Dunn-Holland-Wolfe test, significant differences are labeled by *, note that for better visualization y axis was broken. On panels c,e,f box and whiskers correspond to median, quartile (25−75%) and 10–90% range. Source data of panel c,e and f are provided as a Source Data file.
