Fig. 2: Evaluation of H3S10pho signal over TRCs. | Nature Communications

Fig. 2: Evaluation of H3S10pho signal over TRCs.

From: The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflicts

Fig. 2

a Representative screenshot of a genome region showing co-localization of R-loops (blue) and H3S10pho (orange). b Examples of two R-loop-prone genes (RPL13A and H1-2) showing co-localization with H3S10pho. c Metapeak analysis. H3S10pho mean coverage around +/−5 kb of R-loop peaks. d Venn diagram showing co-occurrence of R-loop-prone genes (DRIPc; blue) and H3S10pho (orange) mark in control K562 cells. e Metanalysis at megabase scale. H3S10pho mean coverage around +/−1 Mb of head-on and co-directional R-loop peaks. Replication fork directionality is indicated. f Analysis of chromatin interactions around TRCs. Replication fork directionality is indicated. TRC transcription-replication conflict, HO head-on, CD co-directional, RF replication fork. Arrows under RF indicate replication fork directionality.

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