Fig. 3: Sample clustering based on immunopeptidomics-derived peptides and HLA haplotype composition. | Nature Communications

Fig. 3: Sample clustering based on immunopeptidomics-derived peptides and HLA haplotype composition.

From: Development of mesothelioma-specific oncolytic immunotherapy enabled by immunopeptidomics of murine and human mesothelioma tumors

Fig. 3

a Hierarchical clustering of immunopeptidome overlap among different samples. The heatmap illustrates the pairwise overlap percentage between each sample. To enhance visualization, overlaps exceeding 40% are capped. b Clustering of samples, including cell lines and resected tumor samples, based on their HLA haplotype composition. The presence of alleles was represented using a one-hot encoding approach. A value of 1 indicates that a specific allele was “found” (represented by gray), while a value of 0 indicates that the allele was “not found” (represented by black). The number of independent samples for the data shown above was: H28 n = 3, 211H n = 6, H2452 n = 4, JL1 n = 2, MESO001 n = 1, MESO002 n = 3. Source data are provided as a Source Data file.

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