Fig. 5: Transcriptomic analysis of brain tissues from ZIKV-infected mice. | Nature Communications

Fig. 5: Transcriptomic analysis of brain tissues from ZIKV-infected mice.

From: A single amino acid substitution in the capsid protein of Zika virus contributes to a neurovirulent phenotype

Fig. 5

CD-1 neonatal mice were inoculated with PBS (Mock), WT or K101R (1 PFU). The samples were harvested on 11 days post-infection. Nine mice were analyzed in total (three for each group). a, b Volcano plots indicating differentially regulated genes of WT- or K101R- infected mouse brains. The numbers of downregulated and upregulated genes were labeled in blue and red, respectively. The mainly upregulated genes in both figures were labeled with gene symbols. c Top 10 Gene Ontology (GO) terms of upregulated and downregulated genes in WT versus mock-infected brains. d Top 10 GO terms of upregulated and downregulated genes in K101R versus mock-infected brains. e–g Heatmap analyses indicated that these upregulated genes were primarily enriched in regulation of cytokine production and defense response as well as inflammatory response. h The top 20 upregulated genes in K101R- versus WT-infected brains of mice. Source data are provided as a Source Data file.

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