Fig. 6: LRRC8A shapes the TCR repertoire in the thymus. | Nature Communications

Fig. 6: LRRC8A shapes the TCR repertoire in the thymus.

From: Cell volume controlled by LRRC8A-formed volume-regulated anion channels fine-tunes T cell activation and function

Fig. 6

TCR-seq analysis of thymocytes from WT (Lrrc8af/f) and KO (Lrrc8af/f, Cd4-Cre) mice (n = 6 mice/group). Age- and sex-matched littermates were used for sequencing (see details in methods). a, b, Complementary determination region 3 (CDR3) distribution of TCR α and β chain. c–e Box-and-whisker plots of the clonality (c) richness (d) and Shannon diversity index (e) for TCR α and β chain with boxes marking first quartile, median, and third quartile and with whiskers extending 1.5 times the inter-quartile range. Each point represents one mouse (n = 6 mice/group). Data are representative of two independent experiments. Unpaired two-sided t test was used in (c–e). Data are presented as mean ± SEM. Source data are provided as a Source Data file.

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