Fig. 8: Proposed model for the control of T cell activation by LRRC8A-formed VRACs. | Nature Communications

Fig. 8: Proposed model for the control of T cell activation by LRRC8A-formed VRACs.

From: Cell volume controlled by LRRC8A-formed volume-regulated anion channels fine-tunes T cell activation and function

Fig. 8

Naïve T cells begin to blast upon TCR activation, and RVD mediated by LRRC8A-formed VRACs limits the cell size. As a result, the TCR signaling molecules are maintained at an appropriate density for optimal T cell activation and blast. In the absence of LRRC8A, T cells lose their regulation of cell size during blast, and TCR signal decays due to the reduced density of signaling molecules. Eventually T cells fail to be adequately activated.

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