Fig. 1: DNA-PAE@BAY-876 nanoassemblies reprogram immunosuppressive TME through TNBC-selective glycolysis inhibition and bispecific PD-L1/CTLA-4 antagonization, leading to enhanced ICT efficacy. | Nature Communications

Fig. 1: DNA-PAE@BAY-876 nanoassemblies reprogram immunosuppressive TME through TNBC-selective glycolysis inhibition and bispecific PD-L1/CTLA-4 antagonization, leading to enhanced ICT efficacy.

From: Inhibition of glycolysis-driven immunosuppression with a nano-assembly enhances response to immune checkpoint blockade therapy in triple negative breast cancer

Fig. 1

a Synthetic route of DNA-PAE@BAY-876 nanoassemblies through the spontaneous organization of the molecular building blocks. b Schematic illustration of DNA-PAE@BAY-876-mediated TME remodeling and the associated immunostimulatory mechanisms.

Back to article page