Fig. 3: Pathogen mutational spectra are influenced by niche.
From: Mutational spectra are associated with bacterial niche

A SBS spectra for the 24 mutational signatures extracted de novo, showing the proportion of each contextual mutation. B Tanglegram showing the relationship between bacterial phylogeny (left hand tree) and mutational signature clustering (right hand tree). Connecting lines show that the composite signature was identified in the corresponding SBS spectrum in at least one signature extraction. Lines are coloured to match the colour of the source genus in the phylogeny, with the exception of signature 15 which was identified in multiple genera and is coloured grey. C We compared the ability of a linear model incorporating genus only and a linear model including both genus and niche to explain mutation type proportions across SBS spectra. LOD scores assessing significance of the improvement in model fit for the model including both genus and niche over the genus only model are shown. Model fits were assessed for each mutation type separately. Points are sized by the improvement in Pearson’s r correlation when including niche over the genus only model. Blue dashed line indicates p = 0.05; points above this line show a significant improvement in model fit. Source data are provided as a Source Data file.