Fig. 4: pSer:alum+ SMNP elicits high autologous nAb titers.

Serum dilution at 50% inhibition of BG505 pseudovirus in a neutralization assay (ID₅₀). Neutralization assays were performed at: a week 12. b week 26. c week 42. NN = non-neutralizing. Neutralization data (Fig. 4a) for Group 1, alum, has been previously published²¹. Mean and SEM or geometric mean and geometric SD are plotted depending on the scale in all figures unless otherwise stated. For Fig. 4a–c, n = 6 per group, with two independent experiments averaged. Statistical significance was tested using either unpaired two-tailed Mann-Whitney tests or Kruskal-Wallis test with Dunn’s multiple comparisons test, depending on the objectives of the study. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Source data are provided as a Source Data File.