Table 1 The number of rats exhibiting drug-induced liver injury estimated by AnimalGAN for the three thiazolidinediones under the 28-day study with high dose in 100,000 rats

From: A generative adversarial network model alternative to animal studies for clinical pathology assessment

Criteria

Troglitazone

Pioglitazone

Rosiglitazone

ALT > ULNa

1230

1820

1467

AST > ULN

7413

4315

4591

TBIL > ULN

3421

2083

2215

ALT > ULN or AST > ULN, and TBIL > ULN

375

161

158

  1. aThe Upper Limit of Normal (ULN) was defined as the highest measurement value observed in the 28-day vehicle-treated control rats.