Table 1 The number of rats exhibiting drug-induced liver injury estimated by AnimalGAN for the three thiazolidinediones under the 28-day study with high dose in 100,000 rats
Criteria | Troglitazone | Pioglitazone | Rosiglitazone |
---|---|---|---|
ALT > ULNa | 1230 | 1820 | 1467 |
AST > ULN | 7413 | 4315 | 4591 |
TBIL > ULN | 3421 | 2083 | 2215 |
ALT > ULN or AST > ULN, and TBIL > ULN | 375 | 161 | 158 |