Fig. 6: Decreased motor cortical inputs to the auditory cortex in Df(16)A+/− mice. | Nature Communications

Fig. 6: Decreased motor cortical inputs to the auditory cortex in Df(16)A+/− mice.

From: Altered corollary discharge signaling in the auditory cortex of a mouse model of schizophrenia predisposition

Fig. 6

a Number of retrogradely labeled neurons in each frontal region in Df(16)A+/− and wild-type mice. b Histological image showing retrogradely labeled neurons in auditory cortical regions contralateral to the injection site. c Number of labeled neurons in contralateral auditory cortical regions in the two genotypes. Area boundaries correspond to the Allen Mouse Brain Atlas. d Retrogradely labeled neurons in the auditory thalamus. e Number of retrogradely labeled neurons in the auditory thalamus in the two genotypes. Scale bars in (b) and (d) represent 1 and 0.5 mm, respectively. Horizontal black lines indicate the average number of neurons across mice in each genotype. M2, secondary motor cortex; M1, primary motor cortex; AC, anterior cingulate cortex; PL, prelimbic cortex; IL, infralimbic cortex; CL, claustrum; SS, somatosensory cortex; AI, anterior insula; OF, orbitofrontal cortex; A1, primary auditory cortex; DA, dorsal auditory cortex; VA, ventral auditory cortex. Data in (a), (c), and (e) is from 10 Df(16)A+/− and nine wild-type mice. P values shown were calculated using a two-sided Wilcoxon rank-sum test. Source data are provided as a Source Data file.

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