Fig. 1: Schematic illustration of synthetic procedures and therapeutic mechanisms of LRT nanomedicine. | Nature Communications

Fig. 1: Schematic illustration of synthetic procedures and therapeutic mechanisms of LRT nanomedicine.

From: Nanomedicine-based co-delivery of a calcium channel inhibitor and a small molecule targeting CD47 for lung cancer immunotherapy

Fig. 1

a Schematic diagram of LDH nanosheet synthesis and the subsequent drug loading. b Mechanism of antitumor immune responses against orthotopic lung tumors by TTA-Q6/RRX-001 co-delivery. (1) T-type calcium influx channel blockage by TTA-Q6, (2) calcium homeostatic deficiency in parallel with the CD47 downregulation by RRX-001, (3) ER stress induction due to the calcium deficiency, (4) calreticulin translocation towards the cell membrane. MΦ represents macrophages.

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