Fig. 3: Disrupting ceramide homeostasis is detrimental to erythroid, but not myeloid, progenitor function. | Nature Communications

Fig. 3: Disrupting ceramide homeostasis is detrimental to erythroid, but not myeloid, progenitor function.

From: A transcriptional network governing ceramide homeostasis establishes a cytokine-dependent developmental process

Fig. 3

a CFU activity of Lin- cells from E14.5 fetal livers treated with or without 4HPR (n = 8 biologically independent samples from 2 independent experiments, mean ± SD). p values were calculated by two-tailed unpaired Student’s test. b Representative Wright-Giemsa staining of cells recovered from day 8 of CFU assays in (a). Scale bars = 50 μm. c CFU activity of Lin- cells from E14.5 fetal livers treated with vehicle (EtOH), C6-dhCer, or C6-Cer (n = 6 biologically independent samples from 2 independent experiments, mean ± SD). p values were calculated using one-way ANOVA followed by Dunnett’s multiple comparisons test. d Representative Wright-Giemsa staining of cells recovered from day 8 of CFU assays in (c). Scale bars = 50 μm. Source data are provided as a Source Data file.

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