Fig. 7: Proposed model of GATA1 conferring ceramide homeostasis to commission cellular signaling mechanisms that govern erythropoiesis. | Nature Communications

Fig. 7: Proposed model of GATA1 conferring ceramide homeostasis to commission cellular signaling mechanisms that govern erythropoiesis.

From: A transcriptional network governing ceramide homeostasis establishes a cytokine-dependent developmental process

Fig. 7

GATA1 controls ceramide homeostasis during erythroid development by regulating sphingolipid biosynthetic enzymes. Disrupting ceramide homeostasis deleteriously impacts erythropoiesis by antagonizing essential SCF and Epo signaling via PP2A-dependent mechanisms.

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