Fig. 1: Distribution of clinically relevant AR genes across global human-associated microbiomes globally and cultured isolates.
The top heatmap shows the prevalence of AR gene families in human gut-associated microbiomes sequenced from each country. Immediately below is a heatmap showing the total prevalence in gut, skin and oral microbiomes. The bottom heatmap shows the prevalence of AR gene families in sequenced isolates by taxonomic class. Color scales represent the percent of metagenomes (top) or isolates (bottom) for which the gene family was detected. At right of the top heatmap are two barplots, one showing the proportion of samples from heathy (blue) and not-healthy (red) individuals, as classified by curatedMetagenomicDataCuration19, and a second showing the total number of samples from each country. At right of the bottom heatmap are two barplots, the first showing the proportion of isolates from pathogenic (yellow), non-pathogenic (red), or unannotated species (gray), as determined by CARD, and the second showing the total number of isolates surveyed per class. At the bottom, a barplot shows the total number of AR gene varients in each gene family (light orange) and the number detected in this study (dark orange) in the metagenomic datasets. Nearly all genes in each family shown were identified in the isolate genomes.
