Fig. 1: Mechanisms of Lyso700D and D-RAWs in vivo.
From: Adoptive macrophage directed photodynamic therapy of multidrug-resistant bacterial infection
a Schematic of adoptive macrophage-directed photodynamic therapy of bacterial infection in hosts. Step I, engineer D-RAWs by staining RAWs with Lyso700D; step II, transfer D-RAWs to infected mice through i.v. injection; step III, engineered D-RAWs track and capture bacteria; step IV, upon irradiation, D-RAWs self-destruct and kill the captured bacteria simultaneously. b Structure and mechanism of action of Lyso700D. Acidity turns up the PDT effect by restricting the photoinduced electron transfer process.
