Fig. 6: Conformational changes in BSEP.
From: Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP
a, b Cartoon representation of the TMDs in GBM-bound BSEP, substrate-free BSEP, TC-bound BSEP, ATP-bound BSEPE1244Q, and vanadate-trapped BSEP. TMDs are numbered and colored orange and green, and TM 4–5 and TM 10–11 are colored red in (a). The distances between TM3 (R201) and TM4 (D282) in TMD1 and between TM9 (A856) and TM11 (F959) in TMD2 are measured and labeled. The numbers in the white circles in b represent the TM helices.
