Fig. 6: A model for GFRα1-directed conformational control of GDNF-dependent signalling.
From: Architecture and regulation of a GDNF-GFRα1 synaptic adhesion assembly
GFRα1 mediates trans-synaptic adhesion following GDNF engagement. D1 proteolytic clipping or D1 sequestration by a GFRα1 binding partner at the cell membrane promotes the formation of a GDNF-GFRα1 decameric trans-synaptic complex. However, in the presence of RET and HS, GFRα1 forms a ternary complex with RET in cis following GDNF engagement, to promote trophic support. RET and HS binding couples the D1:D3 interface and thereby prevents trans-adhesion complex formation.
