Fig. 3: scReadSim generates realistic scATAC-seq sequencing reads with ground-truth peaks. | Nature Communications

Fig. 3: scReadSim generates realistic scATAC-seq sequencing reads with ground-truth peaks.

From: scReadSim: a single-cell RNA-seq and ATAC-seq read simulator

Fig. 3

scReadSim’s synthetic scATAC-seq data mimic the real sci-ATAC-seq dataset23 in terms of the cell-type-specific read coverage (a), the fragment-size distribution (b), the substitution error rate per base within a read (c), and the peaks called by MACS3 at the pseudo-bulk level (d; “Methods”). e scReadSim enables user-designed, cell-type-specific ground-truth (g.t.) peaks for scATAC-seq read generation.

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