Fig. 4: Mucosal-associated invariant T (MAIT) cells protect from renal tissue damage in experimental crescentic glomerulonephritis (cGN).

a Representative photomicrographs of kidney sections from C57BL/6J wild type and B6-MAIT^CAST mice on day 9 of cGN stained with periodic acid-Schiff (PAS) (upper panel) and immunohistochemistry for the neutrophil marker GR-1 (lower panel). Asterisks mark glomerular crescents, arrow heads mark neutrophils in the tubulointerstitial area. b Quantification of crescent formation and tubulointerstitial neutrophil infiltration (C57BL/6J wild type n = 7, B6-MAIT^CAST n = 7; n represents the number of biologically independent animals). c Kidney function parameters in C57BL/6J wild type and B6-MAIT^CAST mice (groups as in b). Data in (a–c) are representative for three independent experiments. d Representative PAS and GR-1 stainings of kidney sections from C57BL/6J wild type and Mr1^−/− mice on day 9 of cGN. Asterisks mark glomerular crescents, arrow heads mark neutrophils in the tubulointerstitial area. e Quantification of crescent formation and tubulointerstitial neutrophil infiltration (C57BL/6J wild type n = 7, Mr1^−/− n = 8; n represents the number of biologically independent animals). f Kidney function parameters in C57BL/6J wild type and Mr1^−/− mice (C57BL/6J wild type n = 7, Mr1^−/− n = 8; n represents the number of biologically independent animals). Data in (d–f) are representative for two independent experiments. Scale bar represents 20 µm. Symbols represent individual animals. Bars represent mean ± SEM. (*p < 0.05, **p < 0.01 in two-sided Student’s t test). Source data are provided as a Source Data file.