Fig. 2: Single neurons in dlPFC signal reward expectation across multiple task periods. | Nature Communications

Fig. 2: Single neurons in dlPFC signal reward expectation across multiple task periods.

From: Dopamine receptor activation regulates reward expectancy signals during cognitive control in primate prefrontal neurons

Fig. 2

A Recording site in dlPFC (area 46) of two macaque monkeys. B Effects of D1R stimulation with SKF81297 (129 neurons, p = 0.008) and D2R stimulation with quinpirole (127 neurons; p < 10−6) on neuronal firing rate in the baseline period. Data are presented as mean values +/- SEM. (signed-rank test, two-sided, ***p < 0.001, **p < 0.01) C Time-resolved reward discriminability quantified via AUROC between spike rate distributions in large and small reward trials throughout the task. Neurons are sorted by the latency of reward discrimination (see Methods) and grouped by their overall reward size preference (above dashed line, overall large-preferring; determined by the average firing rate between reward cue onset and test stimulus onset). D First three temporal components explaining the largest temporal variability in temporal reward discrimination in all recorded neurons. For subsequent analyses, we defined 3 main task periods (gray shaded areas, see text and Methods for details).

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