Fig. 6: D1R and D2R differentially modulated population decoding of reward size across task period.

A Performance (probability of the decoder predicting the correct reward size condition) of a linear decoder predicting the reward size class (large or small) of held-out test trials before (left) and after (right) D1R stimulation based on population activity in the cue period of all recorded neurons in SKF81297 sessions (top row) and quinpirole sessions (bottom row). B Decoder performance difference between control and drug conditions (top, D1R stimulation; bottom, D2R stimulation). C Same display as in (A) for the decoder’s performance based on population activity in the cue delay phase. D Same display as in (B) for the cue delay phase. E Summary and statistical evaluation of D1R (reward cue period: n = 129 neurons, p = 0.014; reward delay1 period: p = 0.013; sample delay2 period: p < 0.1) and D2R stimulation (reward cue period: n = 127 neurons, p = 0.075; reward delay1 period: p = 0.004; sample delay2 period: p > 0.1) of decoder performance across task periods. Data are presented as mean values +/- SEM. F Decoder performance in the cue period dependent on the number of sub-sampled neurons. ^**p < 0.01, ^*p < 0.05, ^†p < 0.1, signed rank test.