Fig. 7: D1R and D2R activation increased neuronal reward size selectivity after reward delivery and showed mixed effects in non-match periods.

A Example neuron selective for reward size after reward delivery recorded during control conditions (left) and after stimulating D1Rs with SKF81297 (right) with higher activity after large rewards (gray shaded area, reward period). B Average normalized activity of neurons selective for reward size in the reward delivery period (gray shaded area) recorded with SKF81297. Activity was pooled over reward cue sets, and the preferred reward size was defined as the reward size condition yielding higher average activity. Error bands represent +/- SEM. C Reward size response (AUROC) after reward delivery compared between control and D1R stimulation. Left: Each point corresponds to one neuron. Right: Average reward discriminability (AUROC) for control and D1R stimulation (21 neurons, p = 0.04). Data are presented as mean values +/- SEM. D Example reward neuron selective for reward size after reward delivery recorded during control conditions (left) and after stimulating D2Rs with quinpirole (right) with higher activity after large rewards. E Same conventions as in (B) for all neurons selective for reward size in the reward period recorded with quinpirole. Error bands represent +/- SEM. F Reward size response (AUROC) after reward delivery compared between control and D2R stimulation. Left: Each point corresponds to one neuron. Right: Average reward discriminability (AUROC) for control and D2R stimulation (20 neurons, p = 0.003). Data are presented as mean values +/- SEM. G Reward discriminability (AUROC) in the non-match test period compared between control and D1R stimulation. Left: Each point corresponds to one neuron. Right: Average reward discriminability (AUROC) for control and D1R stimulation (25 neurons, p = 0.81). Data are presented as mean values +/- SEM. H Reward discriminability (AUROC) in the non-match test period compared between control and D2R stimulation. Left: Each point corresponds to one neuron. Right: Average reward discriminability (AUROC) for control and D2R stimulation (27 neurons, p = 0.046). Data are presented as mean values +/- SEM. n.s. not significant, ^**p < 0.01, ^*p < 0.05, signed rank test.