Fig. 4: Comparison analyses between the inflammatory-high and -low populations in TAK-931-treated cells.

a Schemes of comparative analyses between inflammatory-high and -low populations in TAK-931-treated cells. Inflammatory-high and -low cells in the TAK-931 treatment group are shown in pink and sky blue, respectively. b tSNE plot based on the gene expression of the inflammatory-high (pink) and -low (sky blue) cells administered TAK-931 treatment. c Violin boxplot of enrichment scores in the indicated aneuploid stress-related hallmarks (mitotic spindle, DNA repair, unfolded protein response, and glycolysis) are shown between inflammatory-high (pink) and inflammatory-low (sky blue) cell groups. Plots are two independent experiments. All violin boxplots are defined by center lines (medians), box limits (25th and 75th percentiles), and whiskers (minima and maxima; the smallest and largest data range). Two-sided Welch Two Sample t test p < 0.000, respectively. d InferCNV analyses in HeLa cells treated with DMSO or TAK-931. The heatmap of copy number variation (CNV) in DMSO-treated (upper) and TAK-931-treated (lower) cells is shown. Red and blue indicate increased and decreased chromosomal copy numbers, respectively. e Schemes of comparative analyses between CNV-high (light orange) and -low (light blue) populations. f Violin boxplot of enrichment scores in inflammatory response, TNFA signaling pathway via NF-κB, IL6-JAK-STAT3 signaling, and IL2-STAT5 signaling between CNV-high (light orange) and CNV-low (light blue) cell groups are shown. Plots are two independent experiments. All violin boxplots are defined by center lines (medians), box limits (25th and 75th percentiles), and whiskers (minima and maxima; the smallest and largest data range). Two-sided Welch Two Sample t test p < 0.000, respectively. Source data are provided as a Source Data file.