Fig. 4: Scope of complex molecules and peptides.

Reaction condition: ^a1a (10 equiv.), ethylene (10 bar), 3 (0.3 mmol), Co(acac)₂ (5 mol%), 1,10-Phen (5 mol%), DTBP (3 equiv.), CO (40 bar), PhCF₃ (0.2 M), 120 ^oC, 20 h . ^bAlkene (0.6 mmol), (R, R)-^tBu-Pybox (5 mol%). ^c140 ^oC. ^dRecrystallization.