Fig. 3: Eicosanoid mediation model for the association of body mass index, diabetes, and hypertension with HFpEF. | Nature Communications

Fig. 3: Eicosanoid mediation model for the association of body mass index, diabetes, and hypertension with HFpEF.

From: Eicosanoid and eicosanoid-related inflammatory mediators and exercise intolerance in heart failure with preserved ejection fraction

Fig. 3

Mediation analyses identified 3 eicosanoid metabolites with known molecular identity, which were found to mediate >10% of the association of body mass index, diabetes, and hypertension with HFpEF, including 8(9)-EpETE and 12,13 diHOME. We display the eicosanoid mediation model for the most significant eicosanoid mediator of the association of body mass index, diabetes, and hypertension with HFpEF. In this figure, a represents the effect of the covariate on eicosanoid, b represents the effect of eicosanoid on HFpEF, c represents the total effect of the covariate on HFpEF, and c’ is the residual direct effect of the covariate on HFpEF (independent of mediated effects from eicosanoid). Red arrows represent direction of effect of association (e.g. BMI is positively associated with the eicosanoid mediator and with HFpEF. The eicosanoid mediators are negatively associated with HFpEF). Mediation effect considered significant if mediation effect p-value threshold < 0.05 by mediation analysis. Standardized beta-coefficients are shown. BMI body mass index, HFpEF heart failure with preserved ejection fraction.

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