Fig. 3: Myeloid cell-specific ITGA5 loss perturbs scar remodeling after myocardial infarction. | Nature Communications

Fig. 3: Myeloid cell-specific ITGA5 loss perturbs scar remodeling after myocardial infarction.

From: Protective effects of macrophage-specific integrin α5 in myocardial infarction are associated with accentuated angiogenesis

Fig. 3

A In order to assess scar size after 7-28 days of coronary occlusion, systematic quantification of morphometric parameters was performed by sectioning and staining the entire heart from base to apex. B The area of infarcted myocardium was comparable between groups at the 7-day timepoint; however, Myα5KO mice exhibited significantly larger scars 28 days after infarction (*p < 0.05, ITGA5 fl/fl 7d: n = 14, Myα5KO 7d: n = 12, ITGA5 fl/fl 28d: n = 13, Myα5KO 28d: n = 13 biologically independent experiments). C, D Myα5KO mice had trends towards lower infarct wall thickness and larger infarct volume at the 28-day timepoint that did not reach statistical significance. Statistical analysis was performed using one-way ANOVA, followed by the Sidak post-hoc test. Data are shown as mean values +/- SEM. Source data are provided as a Source Data file. Scale bar = 2 mm.

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