Fig. 3: SETD2 deficient ccRCC displays altered metabolic pathways.
From: SETD2 deficiency accelerates sphingomyelin accumulation and promotes the development of renal cancer
a Schematic representation of the transcriptomics and proteomics analyses of KM and KMS mice. b Heat map of the top 290 altered proteins between KM (n = 9) and KMS (n = 5) mice. Heat map of the top 1072 altered genes between KM (n = 5) and KMS (n = 5) mice. c Volcano plot of gene and protein alterations between KM and KMS mice. Significantly differential proteins (FDR < 0.05 and fold change >1.5) are colored in red (upregulated) and blue (downregulated) in KMS mice compared to KM mice, while others are colored in gray. d Significantly altered KEGG pathways between KM and KMS mice based on differential genes. e Significantly altered KEGG pathways between KM and KMS mice based on differential proteins. f GSEA analysis of upregulated and downregulated pathways in KMS mice compared to KM mice at mRNA (x axis) and protein (y axis) levels based on GO subset in AmiGO database. Normalized enrichment scores (NES) of GO terms are plotted. Source data are provided as a Source Data file.
