Fig. 5: SETD2 loss associates with upregulated sphingomyelin biosynthesis in human ccRCC.
From: SETD2 deficiency accelerates sphingomyelin accumulation and promotes the development of renal cancer
a Sample-averaged, normalized and log-transformed change level for altered protein pairs in human and mouse ccRCC. Up- and down-regulated proteins at both mouse and human ccRCC are shown in red and blue, respectively. b Increased PFKP, SLC16A1, KDSR, LPCAT3 and PFKP proteins, as well as decreased HAAO, GOT2, FABP3, IDH3G and GLYCTK proteins were observed in ccRCC samples compared to adjacent normal kidney tissues (P < 0.0001). c The correlation of key protein abundances and protein level of SETD2 in human ccRCC. d Representative immunofluorescent images showing protein levels of SETD2 in ccRCC patients and representative MALDI-IMS images of ccRCC tissue from the same patients. Statistical comparisons were made using a 2-tailed Student’s t test. Data are represented as mean ± SEM. Source data are provided as a Source Data file.
