Fig. 6: Inhibition of sphingomyelin biosynthesis relieves the tumorigenesis symptom caused by SETD2 deletion in mice.
From: SETD2 deficiency accelerates sphingomyelin accumulation and promotes the development of renal cancer
a Graphic illustration of the workflow and course of treatment. b The longitudinal ultrasonic imaging of tumor development in vehicle- and myriocin-treated KMS mice. Kidneys were indicated by white dotted lines. Scale bars = 2 mm. c, d Body weights and kidney volumes of vehicle- and myriocin-treated KMS mice. Scale bars =1 cm. Representative images (e) and metrics (f) showing protein levels and histologic changes upon the treatment of myriocin. Aberrant areas are indicated by black dotted lines and arrows. The area in the box is enlarged on the right. Scale bars, 50 μm. Statistical comparisons were made using a two-tailed Student t test. Data are represented as mean ± SEM. Source data are provided as a Source Data file.
