Fig. 7: Oral ulcer healing efficacy of PolyLA-Na/PolyLA patch in rat model. | Nature Communications

Fig. 7: Oral ulcer healing efficacy of PolyLA-Na/PolyLA patch in rat model.

From: A self-stabilized and water-responsive deliverable coenzyme-based polymer binary elastomer adhesive patch for treating oral ulcer

Fig. 7

a Scheme depicting creation of rat mucosa defect that was covered by PolyLA-Na/PolyLA patch or chitosan film to assess healing; b Photographs of buccal mucosa ulcers in rats treated by PolyLA-Na/PolyLA patch and chitosan film at the 0, 2, 4, 6, and 8 days; c Wound healing efficiency of the oral ulcers at days 2, 4, 6, and 8 days after treated with PolyLA-Na/PolyLA patch and chitosan film (n = 3); d, e H&E staining and Masson’s trichrome staining of the regenerated oral mucosa at day 4 and 8 days (n = 3 biologically independent samples in each group); f Immunohistochemistry staining of CK13 antibody in regenerated oral mucosa at 8 days; g immunofluorescence staining of iNOS (green) and MPO (red) antibody in regenerated oral mucosa at 4 days; h–j Quantification of expression levels of CK13, iNOS, and MPO in regenerated oral mucosa (n = 3) CK13 cytokeratin 13, iNOS inducible nitric oxide synthase, MPO myeloperoxidase. (All presented data are mean values ± SD from the mean from n = 3 independent measurements on independent samples. All p values were calculated using a two-sided Student’s t test).

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