Fig. 2: The rBOLD-CSF (regional BOLD-cerebrospinal fluid) coupling was associated with the amyloid-beta (Aβ) accumulation locally at the extended default mode network (DMN) areas among the early Aβ accumulators (CSF+/PET-).
From: Resting-state global brain activity affects early β-amyloid accumulation in default mode network
A The two-year (2-y) Aβ accumulation averaged over 19 early accumulators with the longitudinal data showed much higher values in the extended DMN regions, including the DMN and frontoparietal network (FPN). B The averaged map (N = 19) of the rBOLD-CSF coupling was less negative in the DMN regions, suggestive of weaker glymphatic function. C The association between the rBOLD-CSF coupling (adjusted for age and gender) and the 2-y Aβ SUVR change is significant (Spearman’s ρ = 0.48, P = 0.041, two-sided, PFDR-corrected = 0.082; N = 19) in the higher-order brain networks (left), but not so (ρ = 0.037, P = 0.88, PFDR-corrected = 0.88) in the lower-order sensory-motor regions (right). Each dot represents one CSF+/PET− subject. The higher-order area mask covers the DMN and FPN, whereas the lower-order mask includes the sensory, visual, and auditory networks (Figure S3). Source data are provided as a Source Data file. Parcel-based correlations between the two can be found in Fig. S5.
