Fig. 3: Preferential reduction of global BOLD (gBOLD) presence at the higher-order brain networks is correlated with the preferential amyloid-beta (Aβ) accumulation in the same areas.
From: Resting-state global brain activity affects early β-amyloid accumulation in default mode network
A The averaged map of gBOLD presence in the CSF+/PET− subjects (early accumulators) showed a sensory-dominant pattern similar (Spearman’s ρ = − 0.68, P = 0, two-sided) to the rBOLD-CSF (regional BOLD-cerebrospinal fluid) coupling map. B The cross-hierarchical contrast of the 2-y Aβ standardized uptake value ratio (SUVR) change was computed for each subject as the difference between the higher- and lower-order regions. This cross-hierarchy contrast quantifies the extent to which Aβ is preferentially accumulated in the higher-order regions as compared with the lower-order areas. C The gBOLD presence (adjusted for age and gender) at the higher-order brain regions showed the strongest negative correlations with the cross-hierarchical contrast of 2-y Aβ change, suggesting the reduced gBOLD presence in these areas contributes to the preferential Aβ accumulation in the same regions in the following 2 years. D The cross-hierarchical contrast of the gBOLD presence (adjusted for age and gender) is significantly correlated (ρ = − 0.51, P = 0.027; two-sided, N = 19) with that of the 2-year cortical Aβ changes. Each dot represents one CSF+/PET− subject. Source data are provided as a Source Data file.
